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Clinical Research






Welcome to Wagner Kapoor Institute's Research Division

Clinical Trials







  • General Info:

    Our dedicated research team is driven to provide excellence in the pursuit of scientific advancement while fostering a personal investment in patient relationships and their desire for novel treatment options in the fight against common retina diseases such as Age-Related Macular Degeneration, Diabetic Retinopathy, and Retinal Vein Occlusion. Drs. Alan L. Wagner, MD, FACS, FICS, and Kapil G. Kapoor, MD, FACS, FICS, have been clinical research investigators for over 20 years and participated in numerous trials that helped several once-novel therapies to receive FDA approval and become subsequently available to the general patient population. Under the direction of Dr. Kapoor, the research department has grown significantly over the last 5 years. We currently have a large number of studies examining state-of-the-art treatments and devices over a variety of indications and stages (Phases I - IV). Research participants have the opportunity to receive these therapies prior to their general availability! Patients are encouraged to reach out to a member of the Research Department to see if you're a qualified candidate, and Sponsors/CROs are encouraged to reach out to inquire about study participation. 

    Currently Active Studies:

    • Gemini (GEM-CL-10302)
    • Optina (OP41183)
    • Rhone-X (GR41987)
    • Gather2 (ISEE2008)
    • Aqueous Humor Study (DC002703)
    • Gallego (GR41973)
    • Pagoda (GR40550)
    • Pavilion (GR41675)
    • Photon (DME-1934)
    • Archway (GR40548)
    • Portal (GR40549)
    • Yosemite (GR40349)
    • Lucerne (GR40844)
    • Norse 2 (ONS-5010-002)
    • Lumedica (WM562938)

    If you are interested in learning more about these innovative clinical trials, please reach out to our research coordinator at 757-481-4400 x 320. 

    Recent Publications by WMRC in Peer-Reviewed Journals 

    Kapoor KG, Wagner AL. Mineralocorticoid Antagonists in the treatment of Central Serous Chorioretinopathy: A Comparative Analysis. (In press, Ophthalmic Research) 

    Sim J, Kapoor KG, Wagner AL. lntravitreal daptomycin in recalcitrant post-surgical endophthalmitis (In press, Ophthalmology Case Reports) 

    Kapoor KG, Wagner AL. Eplerenone for Polypoidal Choroidal Vasculopathy. (In press, Ophthalmology Case Reports) 

    Kapoor KG, Wagner AL. Love really is IN the eye of the beholder. Int Ophthalmol. 2015 Oct 23. 

    Bakri SJ, Farghaly A, Iezzi R, Kapoor KG. Evaluation of Multiple Dexamethasone lntravitreal Implants in Patients with Macular Edema associated with Retinal Vein Occlusion. Retina. 2015 Sep 28 

    Kapoor KG, Wagner MS. Bevacizumab in Macular Serous Detachments associated with Waldenstrom's Macroglobulinemia. (In Press, Ophthalmic Surgery Lasers and Imaging) 

    Kapoor KG, Barkmeier AJ, Bakri SJ. Optical Coherence Tomography in Retinal Arterial Occlusions: Case Series and Review of the Literature.Semin Ophthalmol. 2013 Sep 27. 

    Iezzi R, Kapoor KG. No face-down positioning and broad internal limiting membrane peeling in the surgical repair of idiopathic macular holes.Ophthalmology. 2013 Oct;120(10):1998-2003. 

    Wagner M, Kapoor KG, Wagner AL. Regarding Coffee Consumption and Association With All-Cause Mortality and Cardiovascular Morbidity. Mayo Clin Proc. 2013 Dec;88(12):1491-2. 

    Kapoor KG, Wagner M, Wagner AL. The sustained release dexamethasone implant: Expanding indications in vitreoretinal disease. (In Press, Seminars in Ophthalmology) 

    Kapoor KG, Hodge DO, St Sauver JL, Barkmeier AJ. Oral Fluoroquinolones and the Incidence of Rhegmatogenous Retinal Detachment and Symptomatic Retinal Breaks: A Population-Based Study. Ophthalmology. 2014 Jan 28.


     Physical Stats: 1,746 sq ft of dedicated research space

     State-of-the-art imaging and diagnostic equipment

     Dedicated visual acuity testing room

     Designated monitoring space with high-speed internet and phone access

     5 dedicated experienced clinical research coordinators

     Dedicated phlebotomists able to participate in Infusion studies

     CPR, IATA, DGR, and GCP certified study staff

     Certified Ophthalmic Technicians and Photographers

     Customized standard operating procedures (SOPs)

     Excellent subject retention and below industry-average screen fails

     Direct oversight by PI/Research Director



Wagner Kapoor Institute

Ophthalmologists & Eye Surgeons located in the Hampton Roads region of Virginia & North Carolina

Welcome to Wagner Kapoor Institute, specializing in diabetic retinopathy, macular degeneration, eye tumors, and the diagnosis and management of complex medical and surgical eye disease. We are the preferred referral for National Retina Centers of Excellence and the preeminent provider of adult and pediatric macula and retina treatments located in the Hampton Roads region of Virginia & North Carolina. Our state-of-the-art facilities offer the latest technology and treatments to save your eyesight.

  • Diabetic Retinopathy 
  • Age-Related Macular Degeneration
  • Retinal Occlusions
  • Retinal Vascular Disease
  • Ocular trauma & retinal detachment
  • Proliferative Vitreoretinopathy
  • Retinal Tears and Holes
  • Macular Pucker
  • Retinopathy of prematurity and other pediatric diseases of the eye
  • Cancers of the eye
  • Second Opinions

Dedicated to saving sight and enhancing lives, we offer our patients nine convenient locations, reduced wait times, and the comfort of the highest level of personal care and expertise. At Wagner Kapoor Institute, we value our patients’ trust and confidence and understand the challenge posed by diminishing eyesight. Our team provides patients and family members with the caring touch and reassurance they need and deserve.

Dr. Alan Wagner is a board certified, fellowship trained ophthalmologist specializing in vitreoretinal surgery. He is Assistant Professor of Ophthalmology at EVMS and the Medical College of Virginia and serves as a research consultant at the Strelitz Diabetes Institute. A highly trained macular and retinal surgeon, Dr. Wagner is on the medical staff at most area hospitals, including pediatric units and children’s hospitals.

Diabetes Eye Care - Dr. Kapoor

Diabetes Eye Care - Dr. Kapoor


Words from our patients

  • Yelp

    "Did a great job with my mother-in-law and her macular degeneration. Great caring staff, on time, efficient, pretty office, and he's really nice."

    Jody W.
  • Healthgrades

    "Dr Wagner helped me when I was having an eye emergency and was in tremendous pain. I highly recommend him and his staff!"

  • Healthgrades

    "I had excellent results from my eye surgery, and would recommend Doctors Wagner and Kapoor. "

  • "The staff and Doctor Wagner are phenomenal. I can't explain enough how great the team is! Wonderful experience."

    Daniel M.
  • "From the fist visit I was treated with respect y all the workers. Dr. Wagner is the best and makes you feel very at ease. They are the best."

    Grace G.
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